Plant developmental modeling

Systems Biology

Our research uses mathematical and computer simulation techniques to investigate questions in plant development. Working in close collaboration with experimental biologists, we develop cellular-level simulation models of hormone signaling and patterning in plant tissue. These models involve a biochemical aspect, genes, proteins, hormones, combined with growing, changing geometry as cells divide and tissues grow. We are interested in the interaction between these two processes. How genes control physical properties of cells resulting in growth, and how this resulting change in geometry and forces feeds back on signaling and gene regulation. With this in mind, we are researching methods to quantify physical properties in plant tissues, to facilitate the construction of biophysically-based simulation models of plant growth.

Research topics

  • Hormone transport-feedback models of plant patterning

  • Computer simulation models of phyllotaxis

  • Force sensing in plant tissue using MEMS

  • Physically-based models of plant tissues and growth

  • Confocal image processing

  • Parallel processing in biological systems

Interdisciplinary

  • Our work combines techniques from Computer Science, Physics, Mathematics, and Biology.

Contact Person

Prof. Dr. Richard S. Smith

University of Bern
Institute of Plant Sciences
Website
Richard.Smith-at-ips.unibe.ch
+41 (0)31 631 52 23


Recent publications

  • Title: Cellular Force Microscopy for in Vivo Measurements of Plant Tissue Mechanics
    Author(s): Routier-Kierzkowska, Anne-Lise; Weber, Alain; Kochova, Petra; et al.
    Source: PLANT PHYSIOLOGY, 158 (4): 1514-1522 APR 2012
    Document type: Article (Details)
  • Title: Elastic Domains Regulate Growth and Organogenesis in the Plant Shoot Apical Meristem
    Author(s): Kierzkowski, Daniel; Nakayama, Naomi; Routier-Kierzkowska, Anne-Lise; et al.
    Source: SCIENCE, 335 (6072): 1096-1099 MAR 2 2012
    Document type: Article (Details)
  • Title: Positional Information by Differential Endocytosis Splits Auxin Response to Drive Arabidopsis Root Meristem Growth
    Author(s): Santuari, Luca; Scacchi, Emanuele; Rodriguez-Villalon, Antia; et al.
    Source: CURRENT BIOLOGY, 21 (22): 1918-1923 NOV 22 2011
    Document type: Article (Details)
  • Auxin influx inhibitors 1-NOA, 2-NOA, and CHPAA interfere with membrane dynamics in tobacco cells
    Lankova, M; Smith, RS; Pesek, B; et al.
    JOURNAL OF EXPERIMENTAL BOTANY 64 (13): 3589-3598 AUG 2010 (Details)